Abstract #4534

The Relationship between Glutamate and BOLD signal changes During Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults - A combined 1H-MRS and fMRI study

H Zhang¹, PW Chiu^1,2, SWH Wong³, T Liu ⁴, GHY Wong⁴, Q Chan⁵, and HKF Mak^1,2,6

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Educational Psychology, Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Philips Healthcare, Hong Kong, Hong Kong, ⁶Alzheimer’s Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong

Glutamate is hypothesized to be the neurotransmitter in mediating BOLD fMRI. In our study, face-name paired-associates (FN-PA) encoding and retrieval tasks are used to investigate the relationship between glutamate and the BOLD signal changes in 72 healthy adults of varying age. Our results showed that [Glx]_abs in the left hippocampus to be significantly positively correlated with the activations in the memory-related circuitry obtained from the FN-PA encoding and retrieval tasks. This might implicate the role of glutamate as the neurotransmitter mediating the BOLD signal changes in the memory tasks.

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