Meeting Banner
Abstract #4540

Working memory decline in patients with amnestic mild cognitive impairment (aMCI) during 2-back tasks

Zhaoxia Qin1, Mengxing Wang1, Jilei Zhang1, Haifeng Lu1, Shuai Xv1, Jianren Liu2, and Xiaoxia Du*1

1East China Normal University, Shanghai, China, 2Shanghai Ninth People's Hospital, Shanghai, China

This study investigated brain functional abnormalities that are specifically related to working memory in amnestic mild cognitive impairment (aMCI) patients using fMRI in combination with an n-back task. Nineteen aMCI patients (aged, 52-78 years, 13 female) and 19 age-and gender-matched healthy adults participated in this experiment. In the task performance, aMCI group had lower accuracy on the 2-back task. The aMCI patients exhibited less areas of activation during performance of the 2-back vs. 0-back tasks, and more deactivation in the default mode network, compared with healthy group. The aMCI patients exhibited decreased activation in dorsolateral prefrontal cortex and supplementary motor cortex during the 2-back vs. 0-back tasks, compared with healthy group.

This abstract and the presentation materials are available to members only; a login is required.

Join Here