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Abstract #4543

Effects of a high-fat diet in the mouse cerebral response to appetite detected by functional diffusion MRI and HRMAS studies

Irene Guadilla1, María José Guillén1, Sebastián Cerdán García-Esteller1, and Pilar López-Larrubia1

1Instituto de Investigaciones Biomédicas CSIC-UAM, Madrid, Spain

Obesity and overweight are common problems in developed world population, affecting to a greater number of children. In young people, it is becoming more usual to diagnose diabetes or heart problems due to fat accumulation. In this work, we wanted to assess the effects of a fat diet in the cerebral response to an appetite stimulus in mice. We evaluated changes in diffusion magnetic resonance imaging parameters and metabolomic profiles. Our results suggest that high fat diet consumption causes alterations in the brain response to appetite that can be signaled by magnetic resonance approaches.

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