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Abstract #4544

Magnetic resonance to characterize the cerebral response to fasting status in a glioblastoma mouse model

Irene Guadilla1, María José Guillén1, Sebastián Cerdán García-Esteller1, and Pilar López-Larrubia1

1Instituto de Investigaciones Biomédicas CSIC-UAM, Madrid, Spain

Involuntary weight loss in patients with cancer is a common secondary effect in tumor pathologies being a cause of weakening and progression of the disease. This phenomenon causes cachexia that is estimated to be the direct cause of at least 20% of cancer deaths. In this line, untreated intracranial glioma-bearing mice develop cachexia, and the use of magnetic resonance imaging characterization of the cerebral response to different appetitive conditions can contribute to the better understanding of the cachectic status. For that, we employed functional diffusion MRI and metabolomic studies in a glioblastoma mouse model.

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