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Abstract #4547

Test-Retest Reproducibility of Cerebral Blood Flow at Rest and During A Vigilance Task

Hengyi Rao1, Fan Yang1, Sihua Xu1, and John A. Detre1

1Center for functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, United States

It is unclear whether ASL test-retest reproducibility would be different between absolute CBF and relative task-induced CBF changes, and across resting and task scans. Here we scanned 15 healthy participants three times in a 5-day well-controlled study while participants were at rest and performing a simple vigilance task. Absolute CBF showed excellent test-retest reliability across three days, which were comparable to performance reliability. However, reliability of task-induced CBF changes were much lower than reliability of absolute CBF, suggesting that absolute CBF rather than relative CBF changes may be a more reliable brain function measurement for longitudinal and clinical studies.

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