Abstract #4549

Calculation of the Susceptibility Effect on the Rate of Transverse Relaxation using Real Microvascular Networks

Xiaojun Cheng¹, Jonathan R. Polimeni^2,3, Louis Gagnon², Anna Devor^4,5, Sava Sakadžić², Richard B. Buxton⁴, and David A. Boas^1,2

¹Department of Biomedical Engineering, Boston University, Boston, MA, United States, ²Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ³Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Departments of Radiology, UC San Diego, La Jolla, CA, United States, ⁵Departments of Neurosciences, UC San Diego, La Jolla, MA, United States

We obtain the exponent in the power law relation of the transverse relaxation rate and the susceptibility difference between vessels and tissue from first-principles calculations using our recently developed VAN model. We find that this exponent is close to 1, and is more uniformly distributed across regions at higher magnetic field strengths. The results from the uniform vascular partitioning relevant for BOLD fMRI are compared, and the exponent is closer to 1 for the latter. These help inform interpretation fo the physiological variables including CMRO2 and CBV from BOLD and contrast-enhanced fMRI respectively.

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