Abstract #4550

fMRI mapping of brain-wide networks to optogenetically-evoked spindle-like activity from somatosensory thalamus

Xunda Wang ^1,2, Alex T. L. Leong^1,2, Karim El Hallaoui^1,2, Celia M. Dong^1,2, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

The brain is a highly complex, interconnected structure with parallel and hierarchical networks distributed within and between neural systems. During information processing in the brain, spontaneous oscillatory neural events such as slow oscillations, spindles and sharp wave ripples provoke global dynamic patterns. We propose that spindle-like optogenetic stimulation can be employed to study global interaction patterns in long-range networks by stimulating the ventral posteromedial thalamus (VPM) thalamocortical excitatory neurons.

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