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Abstract #4556

Non-invasive estimation of fetal lung maturity using MR spectroscopy

Vidya Rajagopalan1,2 and Stefan Bluml2,3

1Radiology and Imaging Services, Children's Hospital Los Angeles, Los Angeles, CA, United States, 2Rudi Schulte Research Institute, Santa Barbara, CA, United States, 3University of Southern California, Los Angeles, CA, United States

Magnetic resonance spectroscopy (MRS) can potentially be used to non-invasively measure the lipid levels in the amniotic fluid (AF), in-utero, to determine fetal lung maturity (FLM). This would eliminate the need to perform invasive and risky amniocentesis solely to determine FLM. In this study we measured the lipid to water ratio in the amniotic fluid of women with normal pregnancies. Our results showed that this ratio remained steady until after 36 gestational weeks at which point it increased exponentially. This indicates that MRS is a potential replacement for amniocentesis for estimating FLM.

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