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Abstract #4557

Feasibility of Estimating Umbilical Vein Oxygen Saturation with Susceptometry-Based Oximetry

Ana E Rodríguez-Soto1, Michael C Langham1, Nadav E Schwartz2, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Pennsylvania, Philadelphia, PA, United States

Quantitative MRI allows the estimation of fetal oxygen transport in vivo, for which knowledge of the oxygen saturation (HbO2) of blood in the umbilical vein (UV) is required. The method of choice to estimate HbO2 in fetal applications is T2-based oximetry, which requires a sequence-specific calibration equation to convert blood T2 to HbO2. Therefore, in the present work we examined the feasibility of using susceptometry-based oximetry (SBO) to measure HbO2 at the UV as it is calibration-free and implementable across field strengths. Results show, in a limited number of participants, no difference in HbO2 measured with both MRI-based oximetric techniques.

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