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Abstract #4558

Estimating global cerebral venous oxygenation in the human fetus using QSM

Brijesh Kumar Yadav1,2, Sagar Buch3, Uday Krishnamurthy1,2, Pavan Jella2, Edgar Hernandez-Andrade4, Anabela Trifan2, Lami Yeo4, Sonia Hassan4, E. Mark Haacke1,2, Roberto Romero4,5, and Jaladhar Neelavalli2,6

1Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, 2Department of Radiology, Wayne State University, Detroit, MI, United States, 3The MRI Institute for Biomedical Research, Waterloo, ON, Canada, 4Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, United States, 5Perinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, United States, 6Philips Innovation Campus, Philips India Limited, Banglore, India

Unobstructed oxygen supply is important for proper health and development of the growing fetus and therefore, fetal cerebral oxygenation measurement has been attempted previously using SWI. However, vessel curvature and oblique fetal orientation posed a major challenge in the oxygenation measurement, especially in younger foetuses. To overcome these problems, we present the first application of quantitative susceptibility mapping for the fetal brain oxymetry. We also studied the effect of resolution on QSM using simulations. Results showed the mean putative fetal cerebral oxygenation was 67%±7% and minimum of 5 voxels around the vessel and 5 slices gives <3% error in oxygenation.

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