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Abstract #4563

Oxygen transfer through the placenta on hyperoxia

Simon Shah1, Nia Jones2, Lucy Edwards1, Richard Bowtell1, and Penny Gowland1,3

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, Nottingham, United Kingdom, 2Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Nottingham, United Kingdom, 3Nottingham University Hospitals NHS Trust and University of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom

Rapid transport of oxygen through the placenta is important to ensure efficient exchange. The aim of this work was to measure the rate of oxygenation distribution across the placenta on hyperoxia using susceptibility mapping. It also attempts to relate the rate of uptake of oxygen in the placenta to the total flow to the placenta. It was observed that upon hyperoxia the susceptibility decreased as the BOLD signal increased in the placenta. We propose that that the rate of homogenization of susceptibility is a marker of transport through the placenta.

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