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Abstract #4567

Proton Spectroscopy of the Human Placenta In-Utero to Establish Normal Ranges Throughout Gestation

David M Morris1,2, Gillian Macnaught1,3, Marian C Aldhous4, Fiona C Denison4, and Scott IK Semple1,3

1Edinburgh Imaging, University of Edinburgh, Edinburgh, United Kingdom, 2MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom, 3BHF Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom, 4MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom

For magnetic resonance proton spectroscopy to be of potential future use in investigating placental dysfunction in-utero, a normal range of detectable metabolites is required. Seventy-seven healthy pregnant women with an uncomplicated singleton pregnancy were scanned between 20 and 40 week's gestation. Robust quality assurance removed compromised data and spectra were quantified for the commonly observed peaks and metabolites expected in the placenta. A characteristic spectrum was observed, which was independent of gestational age. Quantification of this technique in terms of the expected results and their variability will inform future studies and suggest technical improvements that may be useful.

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