Abstract #4566

Placental Functional Imaging with Endogenous Contrast: Preliminary Comparison of BOLD Effect and ASL FAIR in Rhesus Macaque and Human

Ante Zhu^1,2, Kai D. Ludwig³, Wei Zha², Sydney Nguyen⁴, Thaddeus G. Golos^4,5,6, Ian M. Bird⁵, Dinesh M. Shah⁵, Oliver Wieben^2,3, Sean B. Fain^1,2,3, Scott B. Reeder^1,2,3,7,8, Diego Hernando^2,3, and Kevin M. Johnson^2,3

¹Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States, ⁵Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, ⁶Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States, ⁷Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁸Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Non-invasive MRI techniques are needed to quantify placental perfusion and oxygenation during pregnancy. In this work, we assessed the feasibility and correspondence of T2* mapping and arterial spin labeling (ASL) to evaluate placental oxygen delivery. Six pregnant rhesus macaques and seven pregnant women underwent MRI that included T2* mapping and ASL with flow-sensitive alternating inversion recovery (FAIR). Regions of locally high ASL perfusion signal correlated spatially with the regions of locally maximum T2* in animals and humans. The two imaging techniques with endogenous contrast are promising approaches for the detection of oxygen delivery via the placenta.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.