Abstract #4569

Fetal Cardiac Hemodynamics: Initial Experience using 4D flow MRI in Large Animal Models

Eric M. Schrauben¹, Brahmdeep Saini^2,3, Jack R.T. Darby⁴, Jia Yin Soo⁴, Mitchell C. Lock⁴, Elaine Stirrat¹, Aodhnait S. Fahy⁵, Joshua Bradshaw¹, Greg Stortz¹, John G. Sled^1,6, Janna L. Morrison⁴, Mike Seed^7,8, and Christopher K. Macgowan^1,6

¹Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ²Heart Centre, Hospital for Sick Children, Toronto, ON, Canada, ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Sansom Institute for Health Research, University of South Australia, Adelaide, Australia, ⁵Division of General and Thoracic Surgery, Hospital for Sick Children, Toronto, ON, Canada, ⁶Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁷Division of Cardiology, Hospital for Sick Children, Toronto, ON, Canada, ⁸Paediatrics, University of Toronto, Toronto, ON, Canada

4D flow MRI, coupled with advanced surgical preparation of animal subjects, is performed to capture fetal cardiac hemodynamics in two animal models of late gestation pregnancy – pig and sheep. Characterization and visualization of complex flow is presented alongside quantitative measures of flow in major fetal cardiac vessels and shunts.

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