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Abstract #4570

Exploring placental function over gestation using multi-modal functional MRI

Jana Hutter1, Paddy Slator2, Laurence Jackson1, Alison Ho1,3, Ana Dos Santos Gomes1, Anthony N Price1, Daniel Alexander2, Lucy Chappell3, Mary Rutherford1, and Joseph V Hajnal1

1Biomedical Engineering, King's College London, London, United Kingdom, 2Centre for Medical Image Computing, University College London, London, United Kingdom, 3Women's Health Academic Centre, King's College London, London, United Kingdom

The delivery of oxygen and nutrients to the growing fetus in the human placenta is crucial for any successful pregnancy. Major pregnancy complications such as growth restriction and pre-eclampsia have been linked to placental insufficiency. This study attempts to use a comprehensive multi-modal functional MRI approach to visualize and quantify the complexity of the underlying structural and functional processes and monitor their evolution over gestation. The required placenta data can be acquired in the clinically feasible time of ~12 min and requires no contrast agent. The presented acquisition is completed by a dedicated multi-modal pipeline and a set of quantitative features.

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