Abstract #4571

Optimised b-values and Gradient Directions for Placental Diffusion MRI

Paddy J Slator¹, Jana Hutter^2,3, Laurence H Jackson^2,3, Andrada Ianus¹, Ana Dos Santos Gomes², Alison Ho², Lisa Story², Laura McCabe², Eleftheria Panagiotaki¹, Mary Rutherford², Joseph V Hajnal^2,3, and Daniel C Alexander¹

¹Centre for Medical Image Computing and Department of Computer Science, University College London, London, United Kingdom, ²Centre for the Developing Brain, King's College London, London, United Kingdom, ³Biomedical Engineering Department, Division of Imaging Sciences, King's College London, London, United Kingdom

Diffusion MRI (dMRI) has the potential to assess placental microstructure and microcirculation in-vivo, and hence provide insight into conditions such as fetal growth restriction and pre-eclampsia. The utility of dMRI data depends heavily upon the choice of b-values and gradient directions, although these choices have to be weighed against scanning time restrictions. To address these issues, we developed an organ-specific, data-driven, clinically-viable protocol for placental dMRI. This optimised protocol compares favourably with a naive protocol of comparable scan time.

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