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Abstract #4571

Optimised b-values and Gradient Directions for Placental Diffusion MRI

Paddy J Slator1, Jana Hutter2,3, Laurence H Jackson2,3, Andrada Ianus1, Ana Dos Santos Gomes2, Alison Ho2, Lisa Story2, Laura McCabe2, Eleftheria Panagiotaki1, Mary Rutherford2, Joseph V Hajnal2,3, and Daniel C Alexander1

1Centre for Medical Image Computing and Department of Computer Science, University College London, London, United Kingdom, 2Centre for the Developing Brain, King's College London, London, United Kingdom, 3Biomedical Engineering Department, Division of Imaging Sciences, King's College London, London, United Kingdom

Diffusion MRI (dMRI) has the potential to assess placental microstructure and microcirculation in-vivo, and hence provide insight into conditions such as fetal growth restriction and pre-eclampsia. The utility of dMRI data depends heavily upon the choice of b-values and gradient directions, although these choices have to be weighed against scanning time restrictions. To address these issues, we developed an organ-specific, data-driven, clinically-viable protocol for placental dMRI. This optimised protocol compares favourably with a naive protocol of comparable scan time.

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