Abstract #4572

Perfusion MRI of the Placenta by Arterial Spin Labeling (ASL) and Ferumoxytol Dynamic Contrast Enhanced (DCE) MRI in the Rhesus Macaque

Kai D Ludwig¹, Sean B Fain^1,2,3, Sydney Nguyen⁴, Thaddeus G Golos^4,5,6, Scott B Reeder^1,2,3,7,8, Ian M Bird⁶, Oliver E Wieben^1,2, Dinesh M Shah⁶, and Kevin M Johnson^1,2

¹Medical Physics, University of Wisconsin - Madison, Madson, WI, United States, ²Radiology, University of Wisconsin - Madison, Madson, WI, United States, ³Biomedical Engineering, University of Wisconsin - Madison, Madson, WI, United States, ⁴Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madson, WI, United States, ⁵Comparative Biosciences, University of Wisconsin - Madison, Madson, WI, United States, ⁶Obstetrics & Gynecology, University of Wisconsin - Madison, Madson, WI, United States, ⁷Medicine, University of Wisconsin - Madison, Madson, WI, United States, ⁸Emergency Medicine, University of Wisconsin - Madison, Madson, WI, United States

We evaluate two ASL based techniques for non-contrast measurement of perfusion compared with ferumoxytol-based DCE MRI in ten pregnant rhesus macaques. Localized regions of ASL perfusion were observed that coincided with regions of early contrast arrival times and high relative blood flow as seen in DCE, likely identifying locations of material spiral artery inputs into the placenta intervillous space.

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