Abstract #4573

Quantitative ferumoxytol DCE MRI of the primate placenta perfusion domains

Kai D Ludwig¹, Sean B Fain^1,2,3, Erin B Adamson¹, Sydney Nguyen⁴, Thaddeus G Golos^4,5,6, Scott B Reeder^1,2,3,7,8, Ian M Bird⁶, Oliver E Wieben^1,2, Dinesh M Shah⁶, and Kevin M Johnson^1,2

¹Medical Physics, University of Wisconsin - Madison, Madson, WI, United States, ²Radiology, University of Wisconsin - Madison, Madson, WI, United States, ³Biomedical Engineering, University of Wisconsin - Madison, Madson, WI, United States, ⁴Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madson, WI, United States, ⁵Comparative Biosciences, University of Wisconsin - Madison, Madson, WI, United States, ⁶Obstetrics & Gynecology, University of Wisconsin - Madison, Madson, WI, United States, ⁷Medicine, University of Wisconsin - Madison, Madson, WI, United States, ⁸Emergency Medicine, University of Wisconsin - Madison, Madson, WI, United States

The placental vascular network is organized to effectively mediate exchange of nutrients, oxygen, and waste between mother and fetus. We report on the estimated number of placental functional domains in a healthy population of rhesus macaques using ferumoxytol DCE MRI. Noninvasive imaging of the maternal vasculature organization and localized perfusion within the placenta may be a sensitive biomarker to predict pregnancy complications.

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