Abstract #4574

ADC and perfusion fraction f obtained by IVIM model are markers of maternal and fetal human placenta development in normal pregnancy

Amanda Antonelli¹, Silvia Capuani², Michele Guerreri^2,3, Silvia Bernardo¹, Carlo Catalano¹, and Lucia Manganaro¹

¹Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I Università Sapienza di Roma, Rome, Italy, ²Physics Dpt. Sapienza Roma, CNR ISC Roma Sapienza, Rome, Italy, ³SAIMLAL Department, Morphogenesis & Tissue Engineering, Sapienza University of Rome, Roma, Italy

The purpose was to investigate the potential of IVIM model to quantify diffusion and perfusion in human placenta of normal pregnancy. The relation between Apparent diffusion coefficient ADC, perfusion fraction f and pseudo-diffusion coefficient D* obtained in fetal and maternal placenta with microstructural changes occurring during placenta development was investigated. 30 pregnant women (gestational age, GA range = 19-37w) underwent DW examination with b=0,10,30,50,75,100,150,400,700,1000s/mm2. The Pearson correlations between ADC, D*, f and clinical data (GA, Body-Mass Index and basal Glycaemia) were evaluated. ADCvsGA showed significant positive and negative correlation during the II and III trimester of gestation, respectively.

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