Abstract #4576

Metabolic imaging of rodent placenta using hyperpolarized 13C pyruvate MRI

Renuka Sriram¹, Jeremy Gordon¹, Robert A Bok¹, Eugene Milshteyn¹, Daniel B Vigneron¹, Peder E.Z Larson¹, John Kurhanewicz¹, and Priyanka Jha¹

¹University of California, San Francisco, San Francisco, CA, United States

We have demonstrated the initial feasibility of hyperpolarized carbon-13 MRI assessment of placental metabolism in a pregnant rat model using [1-¹³C]pyruvate. This opens avenues for multiple applications investigating metabolic changes of placental dysfunction detrimental to maternal and fetal health.

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