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Abstract #4578

Fast, automated slice prescription of standard anatomical planes for fetal brain MRI

Malte Hoffmann1,2, Borjan Gagoski2,3, Esra A Turk3,4, Paul Wighton1,2, M Dylan Tisdall5, Martin Reuter1,2,6, Elfar Adalsteinsson4, P Ellen Grant2,3, Lawrence L Wald1,2, and André J W van der Kouwe1,2

1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 4Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 5Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 6German Center for Neurodegenerative Diseases, Bonn, Germany

Motion limits MRI of the fetal brain to rapid 2D acquisitions with low resolution. Even with such sequences, it is challenging to obtain images aligned with standard anatomical planes of the brain, and views rendered retrospectively across slices typically suffer from artifacts due to between-slice motion. Here, we present an automated on-scanner slice prescription: immediately before sequence execution, the FOV/slice tilt is updated to match the orientation and position of the brain, derived from the previous acquisition. The fast update is achieved by registration to a template.

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