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Abstract #4582

Use of Multiparametric MRI in assessment of Chronic Kidney Disease: reproducibility, correlation with histology and progression

Charlotte E Buchanan1, Huda Mahmoud2, Eleanor F Cox1, Benjamin L Prestwich1, Nicholas M Selby2, Maarten W Taal2, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, United Kingdom

We use multi-parametric renal MRI including T1, ASL perfusion and DWI to assess structural and haemodynamic changes in CKD patients compared to healthy volunteers (HV). A significant increase in renal cortex and medulla T1 (and reduced corticomedullary differentiation), and reduction in renal cortex perfusion, was found between CKD patients and HVs. MRI measures in CKD patients were highly reproducible. A significant negative correlation was found between renal cortex T1 and eGFR, and a positive correlation of corticomedullary differentiation and perfusion with eGFR. Renal cortex T1 and corticomedullary differentiation correlated most strongly with quantitative biopsy measures of renal interstitial fibrosis (IF).

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