Abstract #4582

Use of Multiparametric MRI in assessment of Chronic Kidney Disease: reproducibility, correlation with histology and progression

Charlotte E Buchanan¹, Huda Mahmoud², Eleanor F Cox¹, Benjamin L Prestwich¹, Nicholas M Selby², Maarten W Taal², and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, United Kingdom

We use multi-parametric renal MRI including T₁, ASL perfusion and DWI to assess structural and haemodynamic changes in CKD patients compared to healthy volunteers (HV). A significant increase in renal cortex and medulla T₁ (and reduced corticomedullary differentiation), and reduction in renal cortex perfusion, was found between CKD patients and HVs. MRI measures in CKD patients were highly reproducible. A significant negative correlation was found between renal cortex T₁ and eGFR, and a positive correlation of corticomedullary differentiation and perfusion with eGFR. Renal cortex T₁ and corticomedullary differentiation correlated most strongly with quantitative biopsy measures of renal interstitial fibrosis (IF).

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