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Abstract #4583

MRI assessment of renal function in Acute Kidney Injury and associated longitudinal changes with recovery

Charlotte E Buchanan1, Huda Mahmoud2, Eleanor F Cox1, Benjamin L Prestwich1, Maarten W Taal2, Nicholas M Selby2, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, United Kingdom

Acute Kidney Injury (AKI), a sudden reduction in kidney function, arises from a number of causes with the degree of renal recovery varying widely between individuals. We use multi-parametric MRI to monitor renal changes at the time of AKI and during the subsequent recovery from AKI. At peak AKI, an increase in renal volume, and both renal cortex and medulla T1 was seen. Medullary T1 significantly correlated with the severity of biochemical injury as measured by serum creatinine, whilst no significant correlation was found for cortex T1. At 3 months post AKI, T1 remained elevated compared to healthy volunteers.

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