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Abstract #4592

Value of endovaginal MRI derived tumor volumes for predicting outcomes in patients selected for trachelectomy vs hysterectomy in cervical cancer

Katja N De Paepe1, Thomas E J Ind2, Ayoma D Attygalle2, Veronica A Morgan2, Karen Thomas2, and Nandita M deSouza1

1Institute of Cancer Research, Sutton, United Kingdom, 2The Royal Marsden NHS Foundation Trust, London, United Kingdom

A pre-surgical endovaginal MRI was performed in 142 women with early stage cervical cancer scheduled for hysterectomy (n=43) or trachelectomy (n=99). Total tumor volume was calculated by summing MRI and LLETZ/biopsy (done prior to imaging) volumes. In the hysterectomy group, tumour volume, grade and lymphovascular space invasion (LVSI) differed significantly between those without and with an adverse outcome (need for adjuvant treatment or recurrence); only volume and LVSI were significant in the trachelectomy group where multivariate analysis demonstrated their independence. In patients eligible for trachelectomy, with tumors >1.4 cm3 and with LVSI, administration of (neo)adjuvant treatment may potentially improve outcome.

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