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Abstract #4596

Multiparametric MRI Data in Diabetic Nephropathy: Correlation with eGFR and eGFR_slope

Lu-Ping Li1, Wei Li1, Bradley Hack1, Orly Kohn2, Stuart Sprague1, and Pottumarthi Prasad1

1NorthShore University HealthSystem, Evanston, IL, United States, 2University of Chicago, Chicago, IL, United States

BOLD, Diffusion and ASL MRI are useful in the evaluation of renal oxygenation, fibrosis and blood flow. In this study, these three functional MRI data were acquired in patients with diabetic nephropathy (DN) patients and stage-3 chronic kidney disease (CKD). For the first time, we report that the cortical blood flow and response to furosemide in renal medulla are significantly correlated with yearly rate of change in eGFR. These relationships were independent of any correlations observed with eGFR. The correlations with eGFR seem to depend on whether a control group was included.

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