DCE-MRI with a 3D spoiled gradient echo sequence and injection of Gd-DTPA was used to analyze the kidney function in mice during septic shock (cecal ligation and puncture CLP model). Gd concentration time courses were analyzed without pharmacokinetic modelling. In renal cortex and medulla of septic mice a slower exponential decay compared to baseline or even non-exponential curve shapes were observed. In most septic mice there was no Gd accumulation in the urine in the bladder. Treatment with an antibody targeting adrenomedullin (a vasodilatory peptide) resulted in a faster half-life of tracer elimination in the kidneys compared to vehicle-treatment.