Abstract #4629

Investigation of the relationship between grey matter volume and cerebrovascular reactivity in aging

Claudine Joëlle Gauthier¹, Dalia Sabra², Brittany Intzandt³, Arno Villringer⁴, Richard D. Hoge⁵, and Christopher J. Steele⁵

¹Physics, Concordia University, Montreal, QC, Canada, ²Université de Montréal, Montreal, QC, Canada, ³Concordia University, Montreal, QC, Canada, ⁴Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁵McGill University, Montreal, QC, Canada

Cerebrovascular reactivity (CVR) is decreased in aging and disease, and is thought to reflect vascular health in the brain. Here, we explore the relationship between grey matter volume (GMV) and CVR in healthy younger and older adults. Results show that this relationship is more complex than previously thought, with a positive relationship between CVR and GMV when GMV is low, but a negative relationship at high GMVs both in younger and older adults. Future analyses will explore the role of cerebral blood flow in this relationship.

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