Meeting Banner
Abstract #4630

Physiology of CO2 and neurovascular coupling: the impact of cerebrovascular reserve on Blood-Oxygenation-Level-Dependent functional MRI measurements

Marco Piccirelli1, Christiaan van Niftrik2, Oliver Bozinov2, Nicolai Maldaner2, Catherine Strittmatter2, Athina Pangalu1, Antonios Valavanis1, Luca Regli2, and Jorn Fierstra2

1Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 2Neurosurgery, University Hospital Zurich, Zurich, Switzerland

We investigate the effect of a general resting state of 40mmHg CO2 as compared to a physiological resting state on BOLD fMRI cerebrovascular reactivity and task based finger-tapping measurements in healthy subjects.

We found that BOLD CVR and fMRI activation are significantly lower when measured at a set ‘‘isocapnic’’ baseline then at the physiological resting CO2. Our second finding is that fMRI signal changes significantly correlates to CVR and both measurements are similarly affected.

This abstract and the presentation materials are available to members only; a login is required.

Join Here