Abstract #4630

Physiology of CO2 and neurovascular coupling: the impact of cerebrovascular reserve on Blood-Oxygenation-Level-Dependent functional MRI measurements

Marco Piccirelli¹, Christiaan van Niftrik², Oliver Bozinov², Nicolai Maldaner², Catherine Strittmatter², Athina Pangalu¹, Antonios Valavanis¹, Luca Regli², and Jorn Fierstra²

¹Neuroradiology, University Hospital Zurich, Zurich, Switzerland, ²Neurosurgery, University Hospital Zurich, Zurich, Switzerland

We investigate the effect of a general resting state of 40mmHg CO2 as compared to a physiological resting state on BOLD fMRI cerebrovascular reactivity and task based finger-tapping measurements in healthy subjects.

We found that BOLD CVR and fMRI activation are significantly lower when measured at a set ‘‘isocapnic’’ baseline then at the physiological resting CO2. Our second finding is that fMRI signal changes significantly correlates to CVR and both measurements are similarly affected.

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