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Abstract #4631

Contribution of Systemic Vascular Effects on White Matter BOLD fMRI Signal

Pinar S Ă–zbay1, Catie Chang1, Dante Picchioni1, Hendrik Mandelkow1, Thomas Moehlman1, Miranda Chappel-Farley1, Peter van Gelderen1, Jacco A de Zwart1, and Jeff H Duyn1

1Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

To probe a potential physiological mechanism behind reported BOLD fMRI signals in white matter (WM), we compared pulse-oximetry signals measured from finger-tip photo-plethysmography (PPG) with fMRI signals recorded simultaneously during an overnight sleep study. Intermittent amplitude (AMP) drops were observed during which WM signal increased and grey matter signal decreased. These findings point to a systemic vascular contribution to WM fMRI signals, driven by AMP drops, and possibly linked to fluctuations in arousal state.

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