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Abstract #4632

Spin Echo measurement of oxygen BOLD reactivity - A simple method for mapping functional capillary blood volume?

Michael Germuska1 and Richard Wise1

1Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom

A simple non-invasive method is presented for the mapping of functional cerebral capillary blood volume. Functional capillary blood volume is a potentially powerful biomarker that is highly correlated with the average rate of glucose metabolism in the tissue. In-vivo maps of capillary blood volume are shown to be highly correlated with resting CBF in healthy volunteers and can be easily acquired within a few minutes with standard MR imaging sequences.

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