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Abstract #4652

Optogenetically-initiated low frequency dorsal hippocampal activity enhances resting-state fMRI connectivity and visual memory retrieval performance

Russell W. Chan1,2,3, Eddie C. Wong1,2, Alex T. L. Leong1,2, Xunda Wang1,2, Celia M. Dong1,2, Karim E. Hallaoui1,2, Lee W. Lim4, and Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, 3Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, 4School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China

Our recent study demonstrated that low frequency optogenetically-initiated hippocampal activities enhances brain-wide resting-state fMRI connectivity. However, the behavioral consequence of such connectivity enhancement remains unknown. Since hippocampus is known to play a prominent role in memory, we assessed the effects of such connectivity enhancement on short-term and long-term memory. Our experimental results demonstrated that, while low frequency dorsal hippocampus stimulation enhanced interhemispheric fMRI connectivity (in hippocampus, V1, A1 and S1), it also improved the long-term visual memory by enhancing memory retrieval (in contrast to memory encoding) performance.

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