Abstract #4653

Left and right temporal lobe epilepsies with mesial temporal sclerosis reveal distinct alterations in the intrinsic effective connectivity within the Papez circuit

Yao-Chia Shih^1,2, Fa-Hsuan Lin¹, Horng-Huei Liou^3,4, and Wen-Yih Isaac Tseng^2,4,5,6

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ²Institute of Medical Device and Imaging, College of Medicine, National Taiwan University, Taipei, Taiwan, ³Department of Neurology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ⁴Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, ⁵Department of Medical Imaging, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ⁶Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

The present resting-state fMRI study performed structural equation modeling to evaluate intrinsic effective connectivity (iEC) within the Papez circuit in patients with unilateral temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Left TLE-MTS is characterized by decreased iEC on the left frontotemporal path, which might be associated with deficits in executive functions and working memory. Right TLE-MTS is characterized by decreased iEC on the paths in the right posterior limbic regions, which might be associated with deficits in autobiographical memory processing. Our findings might facilitate identifying potential epileptic network pathways and developing novel targeted therapies for unilateral TLE-MTS.

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