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Abstract #4654

Tract-specific footprint of functional interhemispheric connectivity in the brain

Jeroen Mollink1,2, Saad Jbabdi2, Michiel Kleinnijenhuis2, Fidel Alfaro-Almagro2, Anne-Marie van Cappellen van Walsum1, Stephen M Smith2, and Karla L Miller2

1Donders Institute for Brain, Cognition and Behaviour, Department of Anatomy, Radboud University Medical Centre, Nijmegen, Netherlands, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Linking the anatomy of neuronal connections to brain function is fundamental to our understanding of how brain architecture underpins human cognition. In this work, we hypothesized that the microstructural features of a white matter pathway relate to functional connectivity between the brain regions it connects. In a large cohort of subjects from UK Biobank, we demonstrate that the functional connectivity of homotopic brain regions from the two hemispheres can be predicted from the microstructure of the tract that connects them.

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