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Abstract #4655

Serotonin transporter occupancy predicts default-mode network connectivity: a SPECT and rsfMRI study

Anouk Schrantee1,2,3, Paul J Lucassen3, Jan Booij1, and Liesbeth Reneman1

1Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Spinoza Centre for Neuroimaging, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands, 3Swammerdam Institute for Life Sciences, Center for Neurosciences, University of Amsterdam, Amsterdam, Netherlands

The serotonergic neurotransmitter system is thought to play a substantial role in modulating the default mode network (DMN). For example, antidepressants (SSRIs) have consistently shown to decrease DMN connectivity. However, it is unclear whether SSRIs also dose-dependently affect DMN connectivity. Therefore, we investigated the association between SERT occupancy by SSRIs (SPECT) and DMN functional connectivity (rs-fMRI). We confirm a dose-dependent effect of SSRIs on connectivity with the DMN; higher SERT occupancy by the SSRI in the thalamus was significantly associated with decreased DMN connectivity. This suggests that DMN connectivity might be interesting biomarker, e.g. for treatment monitoring.

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