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Abstract #4659

Assessing the functional connectivity of hippocampal subfields in healthy controls and TLE: a resting state fMRI study at 7T

Lisanne PW Canjels1,2, Walter Backes1,2, Tamar M van Veenendaal1, Rob PW Rouhl2,3,4, Marielle CG Vlooswijk2,3,4, Albert P Aldenkamp3,4,5, and Jacobus FA Jansen1,2

1Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, 3Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands, 4Epilepsy Center Kempenhaeghe, Heeze, Netherlands, 5Faculty of Electrical Engineering, University of Technology Eindhoven, Eindhoven, Netherlands

It has been suggested that hippocampal subfields show functional specialization. Resting-state functional MRI studies have improved our understanding of brain function. Using rs-fMRI, we examined the possibility of segmenting the hippocampal subfields at 7T and assessed the functional correlations between the hippocampal subfields with other cortical regions. This method was tested in both healthy controls and temporal lobe epilepsy patients. Only small differences in functional connectivity between healthy controls and epilepsy patients were found. This study demonstrated the potential of assessing the resting-state functional connectivity of the hippocampal subfields with other regions of interest in the cortex.

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