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Abstract #4658

Comparison of Spatial Profiles of Activation and Resting State fMRI Signals Across Cortical Depth

Arabinda Mishra1, Feng Wang1, John C Gore1, and Li Min Chen1

1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

FMRI at high spatial resolution is capable of resolving signals from different cortical layers providing the ability to examine local inter-layer information processing. In this study, we quantified the spatial profiles of BOLD fMRI activations and the point spread functions (PSF) of resting state correlations within layers. We found significantly broader extent of stimulus-evoked activity and resting state correlation profiles in the top layer than those in middle and lower layers. These differences may reflect differences in vasculature or neural activity between the layers.

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