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Abstract #4657

Longitudinal Study Functional Reorganization within Resting-state Brain Networks in Subcortical Infarction Stroke Patients

Caihong Wang1, Peifang Miao1, Yafei Guo1, Dandan Zheng2, and Jingliang Cheng1

1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare MR Research China, Beijing, China

In order to identify dynamic evolution model of functional reorganization in stroke patients during recovery process based on the large-scale brain network, eleven meaningful RSNs derived from resting-state data across four consecutive time points within six months in subcortical infarction stroke patients and healthy controls groups were identified using independent component analysis. The results revealed that stroke patients exhibited significantly dynamic functional connectivity changes in the right superior parietal lobule of the dorsal attention network and the cuneus of medial visual networks. Note that functional connectivity to some meaningful brain networks demonstrated consistent alterations over time. The findings may reflect the adaptive reorganization of the functional network in stroke patients.

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