Abstract #4661

Resting state DfMRI revealed alterations of brain activity and network in obsessive–compulsive disorder mouse model

Yoshifumi Abe¹, Yuki Sakai², Hiroaki Hamada³, Norio Takata¹, Yuichi Hiraoka⁴, Tomomi Aida⁴, Kohichi Tanaka⁴, Kenji Doya³, and Kenji Tanaka¹

¹Departemnt of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan, ²ATR Brain Information Communication Research Laboratory Group, Kyoto, Japan, ³Neural Computation Unit and Biological Physics Theory unit, Okinawa Insititute of Science and Technology, Okinawa, Japan, ⁴Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Diffusion fMRI (DfMRI) is a powerful functional imaging method to investigate neural activity and network without BOLD confounding hemodynamic effects. In this study, we applied DfMRI to evaluate brain activity and network of neuropsychiatric disease model, obsessive–compulsive disorder (OCD). Our DfMRI study revealed that the cortex was excited and the hippocampus was inhibited. Functional connectivity analysis of DfMRI detected alterations of cortico-striatal-thalamic networks, in line with the previous study with OCD patients. Additionally, we found that interesting network alterations of the hippocampal networks in this OCD model mice.

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