Abstract #4662

Alterations in resting-state functional connectivity in patients with Crohn’s disease in remission

Jiancheng Hou¹, Rosaleena Mohanty¹, VEENA A NAIR², Poonam Beniwal-Patel³, Vivek Prabhakaran^1,4,5, and Sumona Saha³

¹Radiology, UW-Madison, Madison, WI, United States, ²RADIOLOGY, UW-MADISON, MADISON, WI, United States, ³Medicine, UW-Madison, Madison, WI, United States, ⁴Neurology, UW-Madison, Madison, WI, United States, ⁵Neuroscience Training Program, UW-Madison, Madison, WI, United States

Crohn’s disease (CD) is a chronic inflammatory disorder that commonly affects the small intestine and is a phenotype of inflammatory bowel disease (IBD). Several studies have reported changes in cortical thickness and neurologic deficits in patients with IBD. Here we report alterations in resting state functional MRI connectivity in patients in CD in remission compared to healthy controls, specifically in the executive control and default mode networks. Alterations in resting state functional connectivity in patients with CD may explain some of the mechanisms underlying the development and progression of CD and associated deficits in cognitive and affective functioning.

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