Heroin addiction is increasingly severe in China. Protracted abstinence is commonly used in China. However the effect of protracted abstinence treatment on brain function of heroin dependent patients remains unclear. Previous studies have demonstrated that resting state functional connectivity and amplitude of low frequency fluctuation (ALFF)is useful for studying function of brain.Using the above methods, we found that that prolonged abstinent duration is conducive to function restoring of brain network in heroin-dependent patients, which may be useful to reduce the risk of relapse of heroin addicts.
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