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Abstract #4663

Effect of abstinent duration on brain function in heroin addicts: a resting-state fMRI study

Xin Li1, Qiang Li1, Jiajie Chen1, Wei Li1, Yongbin Li1, Jierong Liu1, Xuan Wei1, Xiaohuai Li1, and Wei Wang1

1Tangdu Hospital, Air Force Military Medical University, Xi'an, China

Heroin addiction is increasingly severe in China. Protracted abstinence is commonly used in China. However the effect of protracted abstinence treatment on brain function of heroin dependent patients remains unclear. Previous studies have demonstrated that resting state functional connectivity and amplitude of low frequency fluctuation (ALFF)is useful for studying function of brain.Using the above methods, we found that that prolonged abstinent duration is conducive to function restoring of brain network in heroin-dependent patients, which may be useful to reduce the risk of relapse of heroin addicts.

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