Abstract #4665

Alteration of resting state functional connectivity following cocaine self-administration

Sung-Ho Lee^1,2, Heather K Decot^1,2,3,4, Fei Fei Wang⁵, Regina M. Carelli^5,6, Yen-Yu Ian Shih^1,2,3,6,7,8, and Garret D Stuber^3,4,6,8

¹Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Curriculum in Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁵Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁶Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁷Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁸Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

We investigate the alteration of resting-state functional connectivity across the brain following self-administration of cocaine in the rat. The result of group-independent component analysis (ICA) and dual regression reveals that cocaine self-administration orchestrates dynamic shifts in co-activity and functional connectivity across resting-state neuronal networks and nodes, several of which that do not directly receive dopamine input.

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