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Abstract #4666

Disease Definition for Schizophrenia by Functional Connectivity using Radiomics Strategy

Long-Biao Cui1,2, Lin Liu3, Yi-Bin Xi1, Wei Qin3, and Hong Yin1

1Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, 2School of Medical Psychology, Fourth Military Medical University, Xi'an, China, 3School of Life Sciences and Technology, Xidian University, Xi'an, China

Specific biomarker reflecting its neurobiological substrates is required for diagnosis and treatment selection of schizophrenia (SZ). We aimed to develop and validate a method of disease definition for SZ by resting-state functional connectivity using radiomics strategy in two data sets. The accuracy was 87.09% for diagnosing SZ patients by applying functional connectivity features, with a validation in the independent replication data set (accuracy = 82.61%). Our findings demonstrate a valid radiomics approach by functional connectivity to diagnose SZ, which is helpful to facilitate objective SZ individualized diagnosis using quantitative and specific functional connectivity biomarker in different sites.

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