Abstract #4667

Functional connectivity MRI in head-fixed awake mice differentiates acute and chronic neuroinflammation

Esteban Adrian Oyarzabal¹, Carolyn Liu², Tzu-Wen Wang¹, and Yen-Yu Ian Shih¹

¹Biomedical Research Imaging Center and Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Differentiating between acute and chronic neuroinflammation could improve clinical diagnoses of Alzheimer's disease, multiple sclerosis, and Parkinson's disease as well as disorders with no established clinical diagnostic methods such as Chronic Traumatic Encephalopathy and Chronic Fatigue Syndrom. This study implements mouse models of acute and chronic neuroinflammation to examine how neuroinflammation alter fcMRI in awake mice.

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