Abstract #4670

BRAIN FUNCTIONAL CHANGES CORRELATE WITH COGNITIVE DYSFUNCTION IN FRIEDREICH'S ATAXIA: AN RS-fMRI STUDY

Sirio Cocozza¹, Teresa Costabile², Enrico Tedeschi¹, Filomena Abate², Camilla Russo¹, Agnese Liguori², Walter Del Vecchio³, Francesca Paciello², Mario Quarantelli³, Alessandro Filla², Francesco Saccà², and Arturo Brunetti¹

¹Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy, ²University of Naples "Federico II", Naples, Italy, ³Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy

We performed a seed-based Resting-State fMRI analysis in Friedreich’s Ataxia (FRDA) patients to assess possible brain functional connectivity (FC) changes in these patients, which are know to be charactherized by an impairment of neuropsychological functions. We found an increased FC in FRDA patients compared to controls in different brain regions, including the medial frontal gryrus, the angular gyri and cingulate gyrus, with a decreased cerebellar FC. Our findings of diffuse alterations of FC in FRDA patients compared to controls may shed new light on the pattern of supratentorial and infratentorial involvement and on dynamics of brain plasticity in this condition.

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