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Abstract #4669

Increased functional connectivity in the SOD1(G93A) animal model of Amyotrophic Lateral Sclerosis: a rs-fMRI study at 4.7T

Pietro Bontempi1, Rachele Podda2, Alice Busato1, Roberta Bonafede2, Ilaria Scambi2, Raffaella Mariotti2, and Pasquina Marzola1

1Department of Computer Science, University of Verona, Verona, Italy, 2Department of Neurosciences, Biomedicine and Movement science, University of Verona, Verona, Italy

To date fMRI studies on Amyotrophic Lateral Sclerosis (ALS) patients are still inconsistent. Here, we performed a rs-fMRI study on a pre-clinical model of ALS with the aim to identify biomarkers at functional level, defining an experimental platform useful for the evaluation of disease progression and therapies development. rs-fMRI was performed in SOD1(G93A) and WT mice using a 4.7T tomograph and an EPI sequence. Our results showed increased functional connectivity in SOD1(G93A) mice at the end-stage of disease. In this work, we defined a functional testbed for ALS animal model and demonstrated the feasibility of rs-fMRI in mice at 4.7T.

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