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Abstract #4672

Functional brain abnormalities in major depressive disorder: evidence from a Chinese multi-site resting-state functional MRI study

Mingrui Xia1,2,3, Tianmei Si4, Xiaoyi Sun1,2,3, Qing Ma1,2,3, Bangshan Liu5, Li Wang4, Jie Meng6,7, Miao Chang8, Xiaoqi Huang9, Ziqi Chen9, Yanqing Tang8, Ke Xu10, Qiyong Gong9, Fei Wang8, Jiang Qiu6,7, Peng Xie11,12,13, Lingjiang Li5, and Yong He1,2,3

1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 2Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China, 3IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China, 4National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health, Peking University the Sixth Hospital, Beijing, China, 5Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, China, 6Department of Psychology, Southwest University, Chongqing, China, 7Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China, 8Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China, 9Huaxi MR Research Center (HMRRC), Department of Radiolog, West China Hospital, Sichuan University, Sichuan, China, 10Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China, 11Institute of Neuroscience, Chongqing Medical University, Chongqing, China, 12Chongqing Key Laboratory of Neurobiology, Chongqing, China, 13The First Affiliated Hospital of Chongqing Medical University, Department of Neurology, China

MDD is characterized by disturbances in mood and cognitive functions; however, the pathophysiological mechanism of MDD is incompletely understood. Using the largest resting-state fMRI MDD dataset in China with 1,434 participants, we revealed significant lower functional coordination in the orbitofrontal and primary sensorimotor and visual cortices and higher coordination in the lateral/medial frontoparietal cortices in MDD. These abnormalities were not affected by medication status but were partially influenced by episode number and onset age in patients. These findings provide solid evidence for functional brain disturbances and crucial insights into neuroimaging-based methods for early diagnosis and therapeutic optimization in MDD.

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