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Abstract #4673

COMT Val158Met polymorphism modulated the relationship between functional connectivity in prefrontal cortex and working memory performance

Sichu Wu1, Zhao Qing1, Jiaming Lu1, Yi Sun1, Ming Li1, Weiping Li1, Yingci Yan1, Xue Liang1, Junxia Wang1, Bin Zhu1, Xin Zhang1, and Bing Zhang1

1Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China

Compared with participants with COMT rs4680-GG, the healthy Han Chinese participants with rs4680-A-allele showed higher degree centrality and functional connectivity in medial prefrontal cortex in resting-state BOLD. The rs4680-A-allele carriers also performed better in 3-back performance than rs4680-GG carriers, and the accuracy of 3-back has significant correlation with functional connectivity value, which indicated that the COMT rs4680 mutation modulated the functional connectivity and working memory performance.

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