Abstract #4674

Reorganization of Homotopic Functional Connectivity in two Profiles of High Potential Children: a resting-state fMRI and DTI Study

Ilaria Suprano¹, Chantal Delon-Martin², Gabriel Kocevar¹, Claudio Stamile¹, Sophie Achard³, Pierre Fourneret⁴, Olivier Revol⁵, Fanny Nusbaum^6,7, and Dominique Sappey-Marinier^1,8

¹CREATIS, Université Claude Bernard Lyon1, Lyon, France, ²Grenoble Institut des Neurosciences (GIN), Université Grenoble Alpe, Grenoble, France, ³GIPSA-lab, Université Grenoble Alpe, Grenoble, France, ⁴Service de Psychopathologie du Développement, Hopital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France, ⁵Service de psychopathologie du développement de l'enfant et de l'adolescent, Hôpital Neurologique, Hospices Civils de Lyon, Bron, France, ⁶Laboratoire Parcours Santé Systémique (P2S), Université de Lyon, Lyon, France, ⁷Centre PSYRENE, Lyon, France, ⁸CERMEP - Imagerie du Vivant, Lyon, France

Several changes were previously found in functional and structural networks of High Potential (HP) children but interhemispheric communication was not investigated. In this study, we studied the homotopic connectivity between pairs of left and right hemispheres regions in three groups of children with standard IQ, homogeneous and heterogeneous high IQ. Functional and structural connectivity were investigated using resting-state fMRI and DTI tractography, respectively, and graph theory for brain network analysis. Our findings showed a reorganization of functional homotopic connectivity involving precuneus, amygdala and frontal pole regions in HP children.

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