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Abstract #4674

Reorganization of Homotopic Functional Connectivity in two Profiles of High Potential Children: a resting-state fMRI and DTI Study

Ilaria Suprano1, Chantal Delon-Martin2, Gabriel Kocevar1, Claudio Stamile1, Sophie Achard3, Pierre Fourneret4, Olivier Revol5, Fanny Nusbaum6,7, and Dominique Sappey-Marinier1,8

1CREATIS, Université Claude Bernard Lyon1, Lyon, France, 2Grenoble Institut des Neurosciences (GIN), Université Grenoble Alpe, Grenoble, France, 3GIPSA-lab, Université Grenoble Alpe, Grenoble, France, 4Service de Psychopathologie du Développement, Hopital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France, 5Service de psychopathologie du développement de l'enfant et de l'adolescent, Hôpital Neurologique, Hospices Civils de Lyon, Bron, France, 6Laboratoire Parcours Santé Systémique (P2S), Université de Lyon, Lyon, France, 7Centre PSYRENE, Lyon, France, 8CERMEP - Imagerie du Vivant, Lyon, France

Several changes were previously found in functional and structural networks of High Potential (HP) children but interhemispheric communication was not investigated. In this study, we studied the homotopic connectivity between pairs of left and right hemispheres regions in three groups of children with standard IQ, homogeneous and heterogeneous high IQ. Functional and structural connectivity were investigated using resting-state fMRI and DTI tractography, respectively, and graph theory for brain network analysis. Our findings showed a reorganization of functional homotopic connectivity involving precuneus, amygdala and frontal pole regions in HP children.

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