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Abstract #4721

Rapid and noninvasive detection and dynamic quantification of gut bleeds with Magnetic Particle Imaging

Elaine Yu1, Prashant Chandrasekharan1, Ran Berzon1, Xinyi Y Zhou1, Zhi Wei Tay1, R Matthew Ferguson2, Amit P Khandhar2, Scott J Kemp2, Bo Zheng1, Patrick Goodwill1,3, Michael F Wendland1, Kannan M Krishnan2,4, Spencer Behr5, Jonathan Carter6, and Steven Conolly1,7

1Department of Bioengineering, University of California, Berkeley, CA, United States, 2Lodespin Labs, Seattle, WA, United States, 3Magnetic Insight, Inc., Alameda, CA, United States, 4Department of Material Science and Engineering, University of Washington, Seattle, WA, United States, 5Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 6University of San Francisco Medical Center, San Francisco, CA, United States, 7Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States

Magnetic Particle Imaging (MPI) is a novel, high-contrast, and quantitative imaging modality that directly detects superparamagnetic iron oxide nanoparticle (SPIO) tracers. These SPIOs have been previously used as a MRI contrast agent. However, with MRI SPIOs are limited by poor specificity and difficulty associated with quantifying the negative signal. Due to its direct detection, high sensitivity and positive contrast, MPI is uniquely poised as a clinically translatable platform for vascular imaging, including gastrointestinal (GI) bleed detection. Here we present in vivo GI bleed detection using long-circulating SPIOs as the vascular agent in a mouse model of Familial Adenomatous Polyposis.

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