Abstract #4721

Rapid and noninvasive detection and dynamic quantification of gut bleeds with Magnetic Particle Imaging

Elaine Yu¹, Prashant Chandrasekharan¹, Ran Berzon¹, Xinyi Y Zhou¹, Zhi Wei Tay¹, R Matthew Ferguson², Amit P Khandhar², Scott J Kemp², Bo Zheng¹, Patrick Goodwill^1,3, Michael F Wendland¹, Kannan M Krishnan^2,4, Spencer Behr⁵, Jonathan Carter⁶, and Steven Conolly^1,7

¹Department of Bioengineering, University of California, Berkeley, CA, United States, ²Lodespin Labs, Seattle, WA, United States, ³Magnetic Insight, Inc., Alameda, CA, United States, ⁴Department of Material Science and Engineering, University of Washington, Seattle, WA, United States, ⁵Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ⁶University of San Francisco Medical Center, San Francisco, CA, United States, ⁷Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States

Magnetic Particle Imaging (MPI) is a novel, high-contrast, and quantitative imaging modality that directly detects superparamagnetic iron oxide nanoparticle (SPIO) tracers. These SPIOs have been previously used as a MRI contrast agent. However, with MRI SPIOs are limited by poor specificity and difficulty associated with quantifying the negative signal. Due to its direct detection, high sensitivity and positive contrast, MPI is uniquely poised as a clinically translatable platform for vascular imaging, including gastrointestinal (GI) bleed detection. Here we present in vivo GI bleed detection using long-circulating SPIOs as the vascular agent in a mouse model of Familial Adenomatous Polyposis.

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