Abstract #4725

Effect of polyphenols during a high-fat diet enhanced with chemical shift-encoded MRI

Angéline Nemeth¹, Hélène Ratiney¹, Benjamin Leporq¹, Kévin Seyssel², Bérénice Segrestin³, Pierre-Jean Valette⁴, Martine Laville³, and Olivier Beuf¹

¹Univ. Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F69621, VILLEURBANNE, France, Lyon, France, ²Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Lausanne, Switzerland, ³Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Centre Hospitalier Lyon Sud, Pierre-Bénite, Lyon, France, ⁴Hospices Civils de Lyon, Département d'imagerie digestive, CHU Edouard Herriot, Lyon, Lyon, France

In this study, 42 healthy male underwent a randomized, double blinded, parallel-group trial with either polyphenols or placebo during 31 days of high-carbohydrate and high-fat overfeeding. Changes in visceral, subcutaneous adipose tissue volumes and liver fat were measured using multi-gradient echo sequence. Visceral, subcutaneous adipose tissue volumes and liver fat increased significantly during overfeeding. The ratio VAT/SAT increased during overfeeding for the placebo group whereas this ratio slightly decreased for the polyphenol group.

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