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Abstract #4725

Effect of polyphenols during a high-fat diet enhanced with chemical shift-encoded MRI

Angéline Nemeth1, Hélène Ratiney1, Benjamin Leporq1, Kévin Seyssel2, Bérénice Segrestin3, Pierre-Jean Valette4, Martine Laville3, and Olivier Beuf1

1Univ. Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F69621, VILLEURBANNE, France, Lyon, France, 2Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Lausanne, Switzerland, 3Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Centre Hospitalier Lyon Sud, Pierre-Bénite, Lyon, France, 4Hospices Civils de Lyon, Département d'imagerie digestive, CHU Edouard Herriot, Lyon, Lyon, France

In this study, 42 healthy male underwent a randomized, double blinded, parallel-group trial with either polyphenols or placebo during 31 days of high-carbohydrate and high-fat overfeeding. Changes in visceral, subcutaneous adipose tissue volumes and liver fat were measured using multi-gradient echo sequence. Visceral, subcutaneous adipose tissue volumes and liver fat increased significantly during overfeeding. The ratio VAT/SAT increased during overfeeding for the placebo group whereas this ratio slightly decreased for the polyphenol group.

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